Hierarchical and context-dependent GR-MR signalling governs endogenous corticosteroid decoding in the heart
Francesca Sacchi, Stefano Boriati, Rocco Caliandro, Silvia Da Pra, Irene Del Bono, Azra Husetić, Chiara Bongiovanni, Carmen Miano, Nicola Pianca, Silvia Mazzone, Alice Cabrini, Riccardo Tassinari, Carlo Ventura, Mattia Lauriola, Monika M Gladka, Gabriele D’Uva
This study shows that corticosteroid responses in the heart are governed by a hierarchical GR-MR signaling mechanism and cellular context, with GR restraining MR output and influencing cardiomyocyte proliferation and fibroblast activation.
bioRxiv · Sep 11, 2026 · PreprintMolecular Biology