Gabriele D’Uva

This study shows that corticosteroid responses in the heart are governed by a hierarchical GR-MR signaling mechanism and cellular context, with GR restraining MR output and influencing cardiomyocyte proliferation and fibroblast activation.

This paper shows that blocking glucocorticoid receptors enhances the effectiveness of growth factors in promoting cardiac regeneration by restoring MAPK/ERK signaling in cardiomyocytes.

This study shows BMP signaling alleviates replication stress in cardiomyocytes, enabling heart regeneration in zebrafish and potentially applicable to humans.

This study identifies BMP7 as a key growth factor promoting cardiomyocyte proliferation in both mouse and zebrafish models, with potential therapeutic applications for heart regeneration.