Monika M Gladka

Hierarchical and context-dependent GR-MR signalling governs endogenous corticosteroid decoding in the heart

This study shows that corticosteroid responses in the heart are governed by a hierarchical GR-MR signaling mechanism and cellular context, with GR restraining MR output and influencing cardiomyocyte proliferation and fibroblast activation.

TBX5 dosage governs ventricular cardiomyocyte maturation, specialization and dedifferentiation in vivo

This study shows how varying TBX5 levels in cardiomyocytes affects their maturation, specialization, and dedifferentiation, revealing a non-linear relationship with cardiac function.

Advancing Nuclei Isolation from Frozen Human Heart for Single-Nucleus RNA Sequencing Applications

This paper presents a standardized nuclei isolation protocol for frozen human heart tissue and a downstream snRNA-seq analysis pipeline, improving yield and consistency in cardiac single-nucleus transcriptomic studies.

A novel and robust method for assessing mitochondrial (dys)function in healthy and diseased frozen cardiac tissue

This paper introduces TSIT, a method to assess mitochondrial function in frozen cardiac tissue, showing comparable results to fresh samples and detecting dysfunction in various mouse models and human samples.