Rocco Caliandro

This study shows that corticosteroid responses in the heart are governed by a hierarchical GR-MR signaling mechanism and cellular context, with GR restraining MR output and influencing cardiomyocyte proliferation and fibroblast activation.

This study shows how varying TBX5 levels in cardiomyocytes affects their maturation, specialization, and dedifferentiation, revealing a non-linear relationship with cardiac function.

This paper presents a standardized nuclei isolation protocol for frozen human heart tissue and a downstream snRNA-seq analysis pipeline, improving yield and consistency in cardiac single-nucleus transcriptomic studies.

This paper introduces TSIT, a method to assess mitochondrial function in frozen cardiac tissue, showing comparable results to fresh samples and detecting dysfunction in various mouse models and human samples.

This paper develops a long-deletion mouse model of Williams syndrome to study vascular and neural phenotypes, finding that Ncf1 modulates both cardiovascular and neuropsychological symptoms.