Sialylated Gangliosides are Required for Plasma Membrane Organization and Neuronal Function
Henry G. Barrow, Zhuang Zhuang Han, Alex S. Nicholson, Sinead Strasser, Daniel A Nash, John Suberu, Robin Antrobus, Daniëlle te Vruchte, David A. Priestman, Stephen C. Graham, Frances M. Platt, Janet Elwyn Deane
The paper shows that sialylated gangliosides are essential for plasma membrane organization and neuronal function, with ST3GAL5 deficiency causing severe disruptions in glycosphingolipid composition and neuronal activity.
bioRxiv · Apr 16, 2026 · PreprintCell Biology