Author

Daniëlle te Vruchte

University of OxfordORCID 0000-0002-1709-1709Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:proteomics· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Frances M. PlattiD· 4 shared David A. PriestmaniD· 2 shared John HardyiD· 2 shared María E. Fernández‐SuáreziD· 2 shared A. Galione· 1 shared Afitz Da SilvaiD· 1 shared Akhilesh PandeyiD· 1 shared Alex S. NicholsoniD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersNeuroscience

Frances M. PlattORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Mice with mono-allelic p.R37H Dhdds variant show aberrant glycosylation and interneuron deficits

Afitz Da Silva, Merrick S. Fallah, Samuel Boris Tene Tadoum, Mehrnaz Fazeli, Irena Josephina Johanna Muffels, Siyan Wang, François Grenier, Rohit Budhraja, Luisa Sturiale, Angela Messina, Moshe Giladi, Mahsa Taherzadeh, Éric Bonneil, Shaukat Khan, Daniëlle te Vruchte, , Alexey V. Pshezhetsky

This study describes a mouse model of DHDDS-CDG, showing seizures, myoclonus, and cognitive deficits linked to glycosylation defects and interneuron abnormalities.

Brain · Sep 11, 2026Peer-reviewedNeuroscience

GPNMB and glycosphingolipid measurements in cerebrospinal fluid and plasma from Parkinson's disease patients

María E. Fernández‐Suárez, Reuben Bush, Erika Di Biase, Daniëlle te Vruchte, David A. Priestman, Mario Cortina‐Borja, Oliver Cooper, John Hardy, Penelope J. Hallett, Ole Isacson A, Frances M. Platt

The paper measures GPNMB and glycosphingolipid levels in CSF and plasma from PD patients and controls, finding sex-based differences and associations with PD biomarkers.

bioRxiv · May 18, 2026 · PreprintNeuroscience

Sialylated Gangliosides are Required for Plasma Membrane Organization and Neuronal Function

Henry G. Barrow, Zhuang Zhuang Han, Alex S. Nicholson, Sinead Strasser, Daniel A Nash, John Suberu, Robin Antrobus, Daniëlle te Vruchte, David A. Priestman, Stephen C. Graham, Frances M. Platt, Janet Elwyn Deane

The paper shows that sialylated gangliosides are essential for plasma membrane organization and neuronal function, with ST3GAL5 deficiency causing severe disruptions in glycosphingolipid composition and neuronal activity.

bioRxiv · Apr 16, 2026 · PreprintCell Biology

Alternative Splicing Directs PMCA2 to Lysosomes and is Linked to Neurodegeneration

María E. Fernández‐Suárez, R. Bush, Jonathan Brenton, Gustavo J.S. Pereira, Melissa Grant‐Peters, Regina Hertfelder Reynolds, Daniëlle te Vruchte, Dawn Shepherd, Y. Weng, Ernesto Artaza-Fernandez, Paweł Lis, Luis Sánchez‐Pulido, Anthony John Morgan, Lianne C. Davis, Diego Gómez‐Coronado, , Frances M. Platt

The paper identifies a splice variant-dependent localization of PMCA2 to lysosomes and links it to neurodegenerative diseases.

bioRxiv · Oct 1, 2025 · PreprintCell Biology