Stephen C. Graham

This study identifies HSV-1 protein pUL56 as responsible for removing voltage-gated ion channels from neuronal plasma membranes, disrupting calcium signaling and neuronal activity.

The paper investigates how the 2A protein interacts with the RNA genome of cardioviruses to activate ribosomal frameshifting through structural changes in the RNA.

The paper shows that sialylated gangliosides are essential for plasma membrane organization and neuronal function, with ST3GAL5 deficiency causing severe disruptions in glycosphingolipid composition and neuronal activity.

This study shows enteroviruses can use two upstream AUGs for translation initiation, with the second AUG providing a competitive advantage in specific host environments.

This paper identifies gpUL141 as a HCMV virion component that modulates envelope glycoprotein trafficking to evade humoral immunity.

This study optimizes HSV-1 infection in human iPSC-derived cortical neurones, enabling efficient and synchronous infection for microscopy and biochemical analysis.

This paper identifies 2B* as an EMCV protein that antagonizes innate immune signaling by interacting with 14-3-3 proteins, specifically through the RRNSS sequence.

This study identifies non-canonical TROPPO motifs in alphaherpesvirus proteins that compete with cellular adaptors for PP1 binding, revealing a novel mechanism of PP1 recruitment.

This study uses 3D correlative fluorescence and X-ray tomography to analyze HSV-1 mutants, revealing roles of viral proteins in morphogenesis and showing envelopment occurs via budding.

This study identifies molecular genotypes and key residues that determine receptor tropism in alphacoronaviruses, revealing generalist and specialist host ranges and potential spillover routes.

This study identifies a retroviral origin of vertebrate myelin by showing that RNLTR12-int retrotransposon regulates myelination through SOX10 interaction in multiple vertebrates.

The paper identifies how Afadin is recruited to PTPRK via its pseudophosphatase domain, revealing that substrate specificity is determined by interactions outside the active site.

The paper shows that altered sulfatide-binding by NF155 links glycosphingolipid imbalances to demyelination by affecting membrane protein abundance and axon-myelin contacts.

This paper elucidates the structural basis of how the Cardiovirus 2A protein regulates gene expression by interacting with RNA elements and ribosomes.

This study investigates how the 2A protein of Theilovirus stimulates ribosomal frameshifting by analyzing its interaction with an RNA pseudoknot and using ribosome profiling.

The paper reveals the structure of the GALC-SapA complex, showing how it processes glycosphingolipids and explains saposin binding specificity.