Henry G. Barrow

This study identifies HSV-1 protein pUL56 as responsible for removing voltage-gated ion channels from neuronal plasma membranes, disrupting calcium signaling and neuronal activity.

The paper shows that sialylated gangliosides are essential for plasma membrane organization and neuronal function, with ST3GAL5 deficiency causing severe disruptions in glycosphingolipid composition and neuronal activity.

This study optimizes HSV-1 infection in human iPSC-derived cortical neurones, enabling efficient and synchronous infection for microscopy and biochemical analysis.

This paper identifies 2B* as an EMCV protein that antagonizes innate immune signaling by interacting with 14-3-3 proteins, specifically through the RRNSS sequence.

This study reveals the conformational dynamics and membrane insertion mechanism of B4GALNT1 in ganglioside synthesis using crystal structures and molecular simulations.

This study uses 3D correlative fluorescence and X-ray tomography to analyze HSV-1 mutants, revealing roles of viral proteins in morphogenesis and showing envelopment occurs via budding.

This study develops i3Neuron models of Tay-Sachs and Sandhoff diseases, revealing plasma membrane remodeling and synaptic dysfunction due to GM2 ganglioside accumulation.