Author

Siobhan McCarthy

Massachusetts General Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1

Frequent Co-Authors

Benjamin P. KleinstiveriD· 1 shared C.K. Fong· 1 shared Casey A. MaguireiD· 1 shared Christian Lacks Lino CardenasiD· 1 shared Christiano R. R. AlvesiD· 1 shared Claire E. ShamberiD· 1 shared David Y. ChungiD· 1 shared Demitri de la Cruz· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBioengineering

Benjamin P. KleinstiverORCID

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Author profile →

1 paper

Recent·Most cited

In vivo Treatment of a Severe Vascular Disease via a Bespoke CRISPR-Cas9 Base Editor

Christiano R. R. Alves, Sabyasachi Das, Vijai Krishnan, Leillani L. Ha, Lauren R. Fox, Hannah E. Stutzman, Claire E. Shamber, Pazhanichamy Kalailingam, Siobhan McCarthy, Christian Lacks Lino Cardenas, C.K. Fong, Takahiko Imai, Sunayana Mitra, Shuqi Yun, Rachael K. Wood, , Patricia Leonor Musolino

This paper develops a customized CRISPR-Cas9 base editor to correct the ACTA2 R179H mutation in a mouse model of MSMDS, improving survival and rescuing vascular and neurological phenotypes.

Nature Biomedical Engineering · Sep 11, 2025Peer-reviewedBioengineering