Author

Siqi Leng

Northwestern University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1

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Research Focus:chromatin & epigenetic regulation· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

Boaz GoldbergiD· 1 shared Christopher H. BohreriD· 1 shared David J. HathcockiD· 1 shared Fenfei LengiD· 1 shared Frances E. HarrisiD· 1 shared Hunter HendrixiD· 1 shared Jie XiaoiD· 1 shared Maxwell WhiteiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiophysics

Boaz GoldbergORCID

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1 paper

Recent·Most cited

Chromosomal Topological Domain Formation Modulates Transcription and the Coupling of Neighboring Genes in Escherichia coli

Nicolás N. Yehya, Christopher H. Bohrer, Qiwei Yu, David J. Hathcock, Boaz Goldberg, Siqi Leng, Frances E. Harris, Hunter Hendrix, Maxwell White, Fenfei Leng, Sam Meyer, Yuhai Tu, Jie Xiao

This study shows that chromosomal topological domains in E. coli repress transcription, reduce orientation effects, and modulate gene coupling through supercoiling changes.

bioRxiv · Nov 23, 2025 · PreprintBiophysics