A Kinetic Scout Approach Accelerates Targeted Protein Degrader Development
Angela T. Fan, Gillian E. Gadbois, Hai‐Tsang Huang, Charu Chaudhry, Jiewei Jiang, Logan H. Sigua, Emily R. Smith, Sitong Wu, Grace J. Poirier, Kara Dunne-Dombrink, Pavitra Goyal, Andrew J. Tao, William R. Sellers, Eric S. Fischer, Katherine A. Donovan, Fleur M. Ferguson
This study develops a kinetic scout approach to accelerate targeted protein degrader development by tuning ligand residence time through chemical proteomics and mechanistic assays.
Angewandte Chemie International Edition · Nov 27, 2024Peer-reviewedPharmacology & Toxicology