Author

Hai‐Tsang Huang

Broad InstituteORCID 0000-0002-4244-2304Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Eric S. FischeriD· 2 shared Katherine A. DonovaniD· 2 shared Andreas MartiniD· 1 shared Andrew J. TaoiD· 1 shared Angela T. Fan· 1 shared Anthony Kairouz· 1 shared Bercin Yildiran· 1 shared Charu ChaudhryiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCell Biology

Eric S. FischerORCID

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2 papers

Recent·Most cited

Proteasomal surveillance of exposed cysteines

Elijah L. Mena, Ken C. Dong, Anthony Kairouz, Katherine A. Donovan, Mostafa A Soliman, Hai‐Tsang Huang, Bercin Yildiran, Eric S. Fischer, Richard I. Sherwood, Richard T. Timms, Andreas Martin, Stephen Joseph Elledge

The paper identifies two proteasomal mechanisms that target proteins with exposed cysteines, revealing their role in quality control and linking them to human diseases.

bioRxiv · Sep 30, 2026 · PreprintCell Biology

A Kinetic Scout Approach Accelerates Targeted Protein Degrader Development

Angela T. Fan, Gillian E. Gadbois, Hai‐Tsang Huang, Charu Chaudhry, Jiewei Jiang, Logan H. Sigua, Emily R. Smith, Sitong Wu, Grace J. Poirier, Kara Dunne-Dombrink, Pavitra Goyal, Andrew J. Tao, William R. Sellers, Eric S. Fischer, Katherine A. Donovan, Fleur M. Ferguson

This study develops a kinetic scout approach to accelerate targeted protein degrader development by tuning ligand residence time through chemical proteomics and mechanistic assays.

Angewandte Chemie International Edition · Nov 27, 2024Peer-reviewedPharmacology & Toxicology