Lineage-specific chromatin poising enforced by ETS-IRF composite elements determines the divergent interferon responses of plasmacytoid dendritic cells and epithelial cells
Gargi Mishra, Snehal Ozarkar, Yo Okamura, Meghan Knoll, Russell Sam, Hongchuan Li, Johannes Schwerk, Adelle P. McFarland, David A. Constant, Hayley Waterman, Manasa Acharya, Adam Lacy‐Hulbert, Jason G. Smith, Michael A. Parthun, Emily A. Hemann, , Ram Savan
This paper identifies lineage-specific chromatin accessibility differences at IFN gene loci in pDCs and epithelial cells, revealing ETS-IRF composite elements as key regulators of divergent interferon responses.
bioRxiv · Jun 10, 2026 · PreprintImmunology