Hierarchical membrane-chromatin tethering buffers nuclear envelope assembly against alterations in lipid flux
Sarah R. Barger, Sofia Sepùlveda, Yang Han, Marc C. Goudge, Shoken Lee, Neale D. Ridgway, Shirin Bahmanyar
The paper shows that hierarchical membrane-chromatin tethering, specifically involving LEM-2 and Emerin, ensures nuclear envelope stability by regulating lipid homeostasis and preventing abnormal nuclear morphology.
bioRxiv · Mar 2, 2026 · PreprintCell Biology