Marc C. Goudge

Amphipathic helices sense the inner nuclear membrane environment through lipid packing defects

The paper identifies how amphipathic helices bind to the inner nuclear membrane by sensing lipid packing defects rather than electrostatics, showing the INM's loose packing under basal conditions.

Hierarchical membrane-chromatin tethering buffers nuclear envelope assembly against alterations in lipid flux

The paper shows that hierarchical membrane-chromatin tethering, specifically involving LEM-2 and Emerin, ensures nuclear envelope stability by regulating lipid homeostasis and preventing abnormal nuclear morphology.