Author

Soha Sohail

Icahn School of Medicine at Mount Sinai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Elena CocciaiD· 2 shared Gustavo Morrone ParfittiD· 2 shared Joel BlanchardiD· 2 shared Tim AhfeldtiD· 2 shared Aisha SatiiD· 1 shared Alban OrdureauiD· 1 shared Andrea Pérez ArévaloiD· 1 shared Anna BrightiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersNeuroscience

Elena CocciaORCID

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2 papers

Recent·Most cited

ATP13A2 Loss of Function-Driven Polyamine Dysregulation Induces SAM Depletion and Epigenetic Astrocyte Toxicity

Elena Coccia, Gustavo Morrone Parfitt, Sundas Ijaz, Aisha Sati, Julia Gesner, Andrea Pérez Arévalo, Jennifer Strong, Anna Bright, Soha Sohail, Thea Deborah Meimoun, Tim Ahfeldt, Peter Vangheluwe, Joel Blanchard

The paper shows ATP13A2 loss of function disrupts polyamine metabolism, leading to SAM depletion and epigenetic astrocyte toxicity, which contributes to Parkinson's disease.

bioRxiv · Apr 6, 2026 · PreprintNeuroscience

Disruption of lysosomal proteolysis in astrocytes facilitates midbrain proteostasis failure in an early-onset PD model.

Gustavo Morrone Parfitt, Elena Coccia, Camille Goldman, Kristen R. Whitney, Ricardo Reyes, Lily Sarrafha, Ki Hong Nam, Soha Sohail, Drew R. Jones, John F. Crary, Alban Ordureau, Joel Blanchard, Tim Ahfeldt

This study shows that impaired lysosomal proteolysis in astrocytes leads to proteostasis failure in midbrain neurons in an early-onset PD model.

Nature Communications · Jan 10, 2024Peer-reviewedNeuroscience