Gustavo Morrone Parfitt

The paper shows ATP13A2 loss of function disrupts polyamine metabolism, leading to SAM depletion and epigenetic astrocyte toxicity, which contributes to Parkinson's disease.

This study identifies GPNMB as a biomarker for lysosomal dysfunction and shows it is secreted via LRRK2-modulated lysosomal exocytosis in macrophages.

This study shows that ATP10B loss causes dopaminergic neuron death and Parkinsonian symptoms in rats and human stem cell models.

This study shows that PSEN1 mutations disrupt regulated intramembrane proteolysis in astrocytes, leading to enhanced inflammatory responses and contributing to familial Alzheimer's disease progression.

This study shows that impaired lysosomal proteolysis in astrocytes leads to proteostasis failure in midbrain neurons in an early-onset PD model.

This study identifies the hippocampal-hypothalamic circuit as a key pathway for context-dependent innate defensive responses through optogenetic manipulation.