Sundas Ijaz

The paper investigates the functional organization of electrical synapses in zebrafish, revealing that Cx34.1 is obligatory while Cx34.7 is accessory, with roles defined by the postsynaptic scaffold, similar to chemical synapses.

The paper shows ATP13A2 loss of function disrupts polyamine metabolism, leading to SAM depletion and epigenetic astrocyte toxicity, which contributes to Parkinson's disease.

The paper uses expansion microscopy to reveal the structural organization of electrical synapses in zebrafish Mauthner cells, showing multiple gap junctions and their association with adherens junction components.

The paper shows that ZO1, a scaffolding protein, is required for Connexin localization at electrical synapses, which is necessary for functional gap junctions and synaptic transmission.