Cardiomyocyte-derived Wnt5a drives doxorubicin-induced cardiomyopathy by amplifying cellular senescence
Eun‐Ah Sung, Peiyong Zhai, Soichiro Ikeda, Masato Matsushita, Koichiro Takayama, Takuma Takada, Nadezhda Fefelova, Lai‐Hua Xie, Ghassan Yehia, Peter J. Romanienko, Varsha Gadiyar, Raymond B. Birge, Daniele Vecchio, Maurizio Forte, Valentina Valenti, , Junichi Sadoshima
This study identifies Wnt5a as a driver of doxorubicin-induced cardiomyopathy by amplifying cellular senescence through a Wnt5a-Fzd2 feed-forward axis.
bioRxiv · Aug 6, 2026 · PreprintCell Biology