Peter J. Romanienko

This study identifies Wnt5a as a driver of doxorubicin-induced cardiomyopathy by amplifying cellular senescence through a Wnt5a-Fzd2 feed-forward axis.

This paper introduces das-CRISPR, a method to achieve monoallelic gene editing in mouse embryos and cell culture by using dCas9 and Cas9 RNPs with the same sgRNA.

This study shows that the KU70 SAP domain is essential for repairing exogenous DNA damage but not for V(D)J recombination or development.

This study shows KAT6A acetylation at K816 enhances AMPK interaction, promoting mitochondrial function and protecting against cardiac hypertrophy in mice.

This paper introduces a new Hoxb8FlpO mouse line and intersectional genetics-viral strategy to target and manipulate developmentally defined adult spinal circuits.

This study shows that the mouse SWS1-SWSAP1 complex is essential for meiotic recombination by promoting RAD51 and DMC1 focus formation, with BRCA2 C terminus playing a modulatory role.