Junichi Sadoshima

This study identifies mitochondrial dysfunction and impaired mitophagy as key drivers of cardiac damage in Fabry disease and shows that L-arginine supplementation can prevent cardiac abnormalities.

This study identifies Wnt5a as a driver of doxorubicin-induced cardiomyopathy by amplifying cellular senescence through a Wnt5a-Fzd2 feed-forward axis.

This study shows that declining NOX4 in skeletal muscle with age disrupts NFE2L2 adaptive homeostasis, leading to muscle dysfunction and systemic aging, which can be mitigated by sulforaphane or exercise.

This study shows that reduced myocardial serine synthesis impairs cardiac stress responses by disrupting redox balance, one-carbon metabolism, and amino acid homeostasis.

This study shows that suppressing autophagy in the heart leads to cardiomyocyte senescence, which worsens cardiac function.