Author

Somnath Mahapatra

University of MichiganPrimary ORCID profile (0000-0001-9490-6353 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Somnath MahapatraiD1 paper · University of Michigan

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 2 Assay:proteomics· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Arul M. ChinnaiyaniD· 3 shared Rahul MannaniD· 3 shared Stephanie J. MineriD· 3 shared Xuhong CaoiD· 3 shared Yuanyuan QiaoiD· 3 shared Eleanor Young· 2 shared Fengyun SuiD· 2 shared Gabriel CruziD· 2 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Arul M. ChinnaiyanORCID

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3 papers

Recent·Most cited

A druggable chromatin vulnerability in suppressive neutrophils restores antitumor immunity

Fan Yang, Yi Bao, Yuanyuan Qiao, Gabriel Cruz, Eleanor Young, Rahul Mannan, Yuping Zhang, Matt Goodrich, Yizhi Cao, Jie Luo, Radha Paturu, Somnath Mahapatra, Jean Ching-Yi Tien, Royce Xu, Mikoto Kobayashi, , Arul M. Chinnaiyan

This paper identifies a druggable chromatin vulnerability in suppressive neutrophils that can restore antitumor immunity through mSWI/SNF antagonists.

bioRxiv · Sep 28, 2026 · PreprintCancer Biology

Rewiring Oncogenic Transcriptional Complexes with Domain-ALTerAtion Chimeras (DALTACs) in Prostate Cancer

Jie Luo, Jianzhang Yang, Jean Ching-Yi Tien, Mi Wang, Sumit Das, Xiaoju Wang, Eleanor Young, Jelena Tošović, Rahul Mannan, Weiguo Xiang, Xia Jiang, Jocelyn Cai, Yihan Liu, Kenneth Gu, Somnath Mahapatra, , Arul M. Chinnaiyan

A bifunctional AR–p300/CBP molecule, DALTAC-1, forces a non-native contact between AR and p300 domains, silences AR enhancers and regresses AR-driven prostate tumors in mice while sparing AR-negative lines.

bioRxiv · Sep 24, 2026 · PreprintCancer Biology✦ In-depth digest

A Stress-Adaptive Lipid Kinase Axis Defines Metabolic Vulnerabilities in Neuroendocrine Prostate Cancer

Yang Zheng, Caleb Cheng, Yizhi Cao, Gabriel Cruz, Yuping Zhang, Radha Paturu, Somnath Mahapatra, Jing Hu, Rahul Mannan, Hüseyin Karabürk, Rupam Bhattacharyya, Yitong Yin, Yi Zhao, Wenyan Liu, Xuhong Cao, , Yuanyuan Qiao

This study identifies a stress-lipid kinase axis in NEPC driven by PIKfyve, revealing a synthetic vulnerability between PIKfyve and FASN that can be exploited for therapeutic targeting.

Cancer Cell · Aug 3, 2026Peer-reviewedCancer Biology