This paper identifies a druggable chromatin vulnerability in suppressive neutrophils that can restore antitumor immunity through mSWI/SNF antagonists.

bioRxiv · Sep 28, 2026 · PreprintCancer Biology

Cellular cartography reveals mouse prostate organization and determinants of castration resistance

Hanbyul Cho, Yuping Zhang, Jean Ching-Yi Tien, Rahul Mannan, Jie Luo, Sathiya Pandi Narayanan, Somnath Mahapatra, Jingzhou Hu, Greg Shelley, Gabriel Cruz, Miriam Shahine, Lisha Wang, Fengyun Su, Rui Wang, Xuhong Cao, , Arul M. Chinnaiyan

This study maps the mouse prostate's cellular organization and identifies key determinants of castration resistance using single-cell and spatial transcriptomics.

Proceedings of the National Academy of Sciences · Aug 25, 2025Peer-reviewedCancer Biology

Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancer

Caleb Cheng, Jing Hu, Rahul Mannan, Tongchen He, Rupam Bhattacharyya, Brian Magnuson, Jasmine P. Wisniewski, Sydney Peters, Saadia A. Karim, David MacLean, Hüseyin Karabürk, Li Zhang, Nicholas J. Rossiter, Yang Zheng, Lanbo Xiao, , Arul M. Chinnaiyan

This study identifies PIKfyve as a targetable vulnerability in pancreatic cancer by showing its role in lipid metabolism and synthetic lethality with KRAS-MAPK inhibitors.

Nature · Apr 23, 2025Peer-reviewedCancer Biology

PIKfyve controls dendritic cell function and tumor immunity

Jae Eun Choi, Yuanyuan Qiao, Ilona Kryczek, Jiali Yu, Jonathan K. Gurkan, Yi Bao, Mahnoor Naseer Gondal, Jean Ching-Yi Tien, Tomasz Maj, Sahr Yazdani, Abhijit Parolia, Houjun Xia, Jiajia Zhou, Shuang Wei, Sara Grove, , Arul M. Chinnaiyan

This study shows that PIKfyve inhibition enhances dendritic cell function and improves immunotherapy efficacy in tumor models.

Nature Communications · Jun 28, 2024Peer-reviewedCancer Biology