Non-canonical immune response to the inhibition of DNA methylation via stabilization of endogenous retrovirus dsRNAs
Yongsuk Ku, Joo‐Hwan Park, Ryeongeun Cho, Yong-Ki Lee, Hyoung-Min Park, Min A Kim, Kyunghoon Hur, Soo Young Byun, Jun Liu, Young-suk Lee, David Shum, Dong‐Yeop Shin, Youngil Koh, Je‐Yoel Cho, Sung‐Soo Yoon, , Yoosik Kim
The paper identifies dsRNA-binding proteins that mediate decitabine's effects by stabilizing ERV RNAs, showing low Stau1 and TINCR expression correlates with poor treatment outcomes in AML patients.
Proceedings of the National Academy of Sciences · Mar 24, 2021Peer-reviewedMolecular Biology