RNA splicing factor mutations drive myeloid neoplasm oncogenesis through protein complex poisoning
Pedro Luís Moura, Rui Mamede Branca, Yaroslav Kaminskiy, Ioannis Siavelis, Kovi R Shrung, Sophia Hofmann, Christina Maria Perraki, Alexandra Argyriou, Sadaf Fazeli, Masahiro M Nakagawa, Teresa Mortera Blanco, Steffen Boettcher, Caroline Kubaczka, Thorsten M. Schlaeger, Maria Creignou, , Eva Hellström-Lindberg
This study identifies how RNA splicing factor mutations drive myeloid neoplasm by disrupting proteomic networks through mis-splicing, validated via single-cell transcriptomics and proteomics.
bioRxiv · Sep 30, 2026 · PreprintCancer Biology