Pedro Luís Moura

This study compares proteomic profiles of steady-state and cultured human erythroid progenitors, revealing how culture-induced stress alters protein expression and erythroid maturation dynamics.

This study identifies how RNA splicing factor mutations drive myeloid neoplasm by disrupting proteomic networks through mis-splicing, validated via single-cell transcriptomics and proteomics.

SpliceUp detects SF3B1-mutant cells in scRNA-seq data by analyzing aberrant splicing signatures, improving detection from low-coverage datasets.

This study identifies UBA1 mis-splicing as a therapeutic target in SF3B1-mutant myelodysplastic syndromes, showing that UBA1 inhibition sensitizes these cells to treatment.

This study shows that complete absence of GLUT1 in human erythroid cells does not impair differentiation or membrane properties, but leads to metabolic changes and increased oxidative stress.