Author

Ioannis Siavelis

Science for Life Laboratory

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Janne LehtiöiD· 3 shared Rozbeh JafariiD· 2 shared Tom ErkersiD· 2 shared Albin ÖsterroosiD· 1 shared Alexandra Argyriou· 1 shared Ann-Charlotte BjörklundiD· 1 shared Anna Bohlin· 1 shared Annika I. JohanssoniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

Janne LehtiöORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

RNA splicing factor mutations drive myeloid neoplasm oncogenesis through protein complex poisoning

Pedro Luís Moura, Rui Mamede Branca, Yaroslav Kaminskiy, Ioannis Siavelis, Kovi R Shrung, Sophia Hofmann, Christina Maria Perraki, Alexandra Argyriou, Sadaf Fazeli, Masahiro M Nakagawa, Teresa Mortera Blanco, Steffen Boettcher, Caroline Kubaczka, Thorsten M. Schlaeger, Maria Creignou, , Eva Hellström-Lindberg

This study identifies how RNA splicing factor mutations drive myeloid neoplasm by disrupting proteomic networks through mis-splicing, validated via single-cell transcriptomics and proteomics.

bioRxiv · Sep 30, 2026 · PreprintCancer Biology

Proteomic profiling reveals pleiotropic antimetabolite activity of triciribine in acute lymphoblastic leukemia

Xuekang Qi, Georgios Mermelekas, Ondřej Hodek, Luay Aswad, Quentin Glaziou, Isabelle Rose Leo, Nona Struyf, Ioannis Siavelis, Henri Colyn Bwanika, Owen F.J. Hovey, Martin Haraldsson, Annika I. Johansson, Tom Erkers, Katja Pokrovskaja Tamm, Janne Lehtiö, Rozbeh Jafari

This study identifies triciribine's pleiotropic antimetabolite effects in ALL by showing its ADK-dependent activity and impact on multiple cellular pathways.

bioRxiv · Mar 16, 2026 · PreprintCancer Biology

Pathway activation model for personalized prediction of drug synergy

Quang Thinh Trac, Yue Huang, Tom Erkers, Päivi Östling, Anna Bohlin, Albin Österroos, Mattias Vesterlund, Rozbeh Jafari, Ioannis Siavelis, Helena Bäckvall, Santeri Kiviluoto, Lukas M. Orre, Mattias Rantalainen, Janne Lehtiö, Sören Lehmann, , Trung Nghia Vu

This paper introduces DIPx, a model predicting drug synergy using pathway activation scores, showing better performance than existing methods on both known and novel drug combinations.

eLife · Jun 3, 2025Peer-reviewedBioinformatics