Dual role of the RIG-I 2CARD as a signaling module and a brake on dsRNA translocation
Sota Kondo, Jiayan Zhang, Keisuke Matsushima, Nina Kurihara, Holger Flechsig, Kenichi Umeda, Noriyuki Kodera, Kazuki Kato, Mikihiro Shibata
This study shows the RIG-I 2CARD acts as both a signaling module and a brake on dsRNA translocation using high-speed atomic force microscopy.
bioRxiv · Oct 14, 2026 · PreprintBiophysics