Mikihiro Shibata

This study shows the RIG-I 2CARD acts as both a signaling module and a brake on dsRNA translocation using high-speed atomic force microscopy.

This study uses HS-AFM to directly observe conformational changes in FGFR1 during signal transduction, showing that autophosphorylation enables dynamic interactions with FRS2.

This study shows that CaMKII holoenzymes form worm-like mesoscale clusters under spatial confinement, with activation leading to cluster expansion and a mutant variant forming clusters even without activation.

The paper uses high-speed AFM to show that CaMKII/{beta} heterododecamers form stable structures with adjacent CaMKII{beta} subunits, revealing their structural role.

This study determines the cryo-EM structure of the heterohexameric LGI1-ADAM22 complex and visualizes its dynamics using high-speed atomic force microscopy.

This study uses HS-AFM to visualize NTD dynamics of GluA2-γ2, showing dimer splitting and its role in synaptic clustering.

The paper uses high-speed atomic force microscopy to study activity-dependent structural dynamics of CaMKII in rat, hydra, and C. elegans, revealing species-specific structural changes and phosphatase tolerance in rat CaMKII.