Keisuke Matsushima

This study shows the RIG-I 2CARD acts as both a signaling module and a brake on dsRNA translocation using high-speed atomic force microscopy.

This study shows that CaMKII holoenzymes form worm-like mesoscale clusters under spatial confinement, with activation leading to cluster expansion and a mutant variant forming clusters even without activation.

The paper uses high-speed AFM to show that CaMKII/{beta} heterododecamers form stable structures with adjacent CaMKII{beta} subunits, revealing their structural role.