Author

Jiayan Zhang

California NanoSystems InstituteORCID 0000-0003-3602-1199Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

Kazuki KatoiD· 2 shared Nina KuriharaiD· 2 shared A. Maeda· 1 shared Akiko Shimazaki-Takahashi· 1 shared Antonella NotarnicolaiD· 1 shared Begum HoruluogluiD· 1 shared Caroline GrönwalliD· 1 shared Celia Torres-AranciviaiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiophysics

Kazuki KatoORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

BiophysicsbioRxivPreprintOct 14, 2026

Dual role of the RIG-I 2CARD as a signaling module and a brake on dsRNA translocation

Sota Kondo, Jiayan Zhang, Keisuke Matsushima…·Mikihiro Shibata

This study shows the RIG-I 2CARD acts as both a signaling module and a brake on dsRNA translocation using high-speed atomic force microscopy.

DOI 10.64898/2026.10.13.758695

experimental assay

𝕏 PostBluesky

BiochemistrybioRxivPreprintJul 31, 2026

✦ In-depth digest

MDA5 multimerization on LINE RNA drives pathogenic extracellular immune complexes in autoimmunity

T. Hsu, Xi Wang, Jiayan Zhang…·Sun Hur

Patient-derived anti-MDA5 antibodies bind MDA5 filaments in two germline-encoded modes; only filament immune complexes activate innate immunity, with LINE-derived dsRNA scaffolding circulating filaments in patient plasma.

DOI 10.64898/2026.01.27.702129

humanprotein structure

𝕏 PostBluesky

Cell BiologyBiological ImagingPeer-reviewedJan 1, 2024

TomoNet: A streamlined cryoET software pipeline with automatic particle picking on flexible lattices

Hui Wang, Shiqing Liao, Xinye Yu…·Z. Hong Zhou

TomoNet is a cryoET software pipeline with automatic particle picking and subtomogram averaging, achieving high-resolution 3D structures from flexible lattices.

13 citations

cryo-EMdeep learning

𝕏 PostBluesky