Kazuki Kato

This study shows the RIG-I 2CARD acts as both a signaling module and a brake on dsRNA translocation using high-speed atomic force microscopy.

Patient-derived anti-MDA5 antibodies bind MDA5 filaments in two germline-encoded modes; only filament immune complexes activate innate immunity, with LINE-derived dsRNA scaffolding circulating filaments in patient plasma.

This paper introduces PRECISE, a method for programmable RNA editing that enables precise insertion, substitution, and deletion of RNA sequences in pre-mRNAs, with high efficiency and fidelity.

This study characterizes the RNA-guided nuclease-protease complex Cas7-11-Csx29, showing target RNA binding activates Csx29 to cleave Csx30, leading to cell death.