Embryological cellular origins and hypoxia-mediated mechanisms in PIK3CA-Driven refractory vascular malformations
Sota Torii, Keiki Nagaharu, Nanako Nakanishi, Hidehito Usui, Yumiko Hori, Katsutoshi Hirose, Satoru Toyosawa, Eiichi Morii, Mitsunaga Narushima, Yoshiaki Kubota, Osamu Nakagawa, Kyoko Imanaka-Yoshida, Kazuaki Maruyama
This study identifies embryonic origins and hypoxia-driven mechanisms in PIK3CA-driven vascular malformations, showing that HIF-1 and VEGF-A inhibition reduces abnormalities.
bioRxiv · Oct 16, 2024 · PreprintMolecular Biology