Keiki Nagaharu

The paper shows fetal hematopoietic stem and progenitor cells (HSPCs) have greater lineage plasticity than adult HSPCs, linked to chromatin accessibility differences.

This study shows that VEGF-C treatment promotes cardiac lymphangiogenesis, reduces inflammation, and preserves heart function in autoimmune myocarditis in mice.

This study identifies embryonic origins and hypoxia-driven mechanisms in PIK3CA-driven vascular malformations, showing that HIF-1 and VEGF-A inhibition reduces abnormalities.

ExDyn is a deep generative model that estimates single-cell transcriptome dynamics influenced by extrinsic factors, showing improved accuracy over existing methods.