Kazuaki Maruyama

This study investigates how dysregulated flow responses in endothelial cells contribute to Sturge-Weber syndrome pathogenesis using cellular models and omics analyses.

This study shows that VEGF-C treatment promotes cardiac lymphangiogenesis, reduces inflammation, and preserves heart function in autoimmune myocarditis in mice.

This study identifies a biophysical mechanism of SOX18/NR2F2 transcriptional antagonism that governs venous differentiation and shows that inhibiting SOX18 can improve vascular malformation symptoms.

This study identifies embryonic origins and hypoxia-driven mechanisms in PIK3CA-driven vascular malformations, showing that HIF-1 and VEGF-A inhibition reduces abnormalities.

This study examines human lymphatic vessel development in embryos and fetuses, finding Prox1-expressing LECs originate from cardinal veins and showing organ-specific developmental patterns.

This study identifies the cardiopharyngeal mesoderm as a non-venous source of lymphatic endothelial cells contributing to craniofacial and cardiac lymphatic networks.