Author

Osamu Nakagawa

National Cerebral and Cardiovascular Center Research InstituteORCID 0000-0002-3858-6903Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Akashi Taguchi· 1 shared Akinori KanaiiD· 1 shared Akiyasu IwaseiD· 1 shared Chisa ShukunamiiD· 1 shared Daiki SeyaiD· 1 shared Eiichi MoriiiD· 1 shared Haruhiko AkiyamaiD· 1 shared Hidehito UsuiiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperDevelopmental Biology

Akashi Taguchi

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2 papers

Recent·Most cited

Hox-Meis-relayed gene regulatory transition underlies cardiopharyngeal neural crest diversification

Akiyasu Iwase, Yasunobu Uchijima, Daiki Seya, Mayuko Kida, Hiroki Higashiyama, Kazuhiro Matsui, Akashi Taguchi, Yukihiro Harada, Yunce Wang, Shogo Yamamoto, Shiro Fukuda, Seitaro Nomura, Takahide Kohro, Chisa Shukunami, Haruhiko Akiyama, , Hiroki Kurihara

The paper maps lineage trajectories and gene regulatory networks of cardiopharyngeal neural crest cells in mice, identifying a Hox-Meis-regulated transition associated with cardiac cushion development.

bioRxiv · Nov 9, 2025 · PreprintDevelopmental Biology

Embryological cellular origins and hypoxia-mediated mechanisms in PIK3CA-Driven refractory vascular malformations

Sota Torii, Keiki Nagaharu, Nanako Nakanishi, Hidehito Usui, Yumiko Hori, Katsutoshi Hirose, Satoru Toyosawa, Eiichi Morii, Mitsunaga Narushima, Yoshiaki Kubota, Osamu Nakagawa, Kyoko Imanaka-Yoshida, Kazuaki Maruyama

This study identifies embryonic origins and hypoxia-driven mechanisms in PIK3CA-driven vascular malformations, showing that HIF-1 and VEGF-A inhibition reduces abnormalities.

bioRxiv · Oct 16, 2024 · PreprintMolecular Biology