Small molecule modulator of neuronal lysosome positioning and function resolves Alzheimers Disease-linked pathologies in cultured human neurons
Amanda M. Snead, Sruchi Patel, Mia Krout, Ryan S. Hippman, Gabrielle Smith, Diya Dileep, Nitya Chagoor, Rachel Shi, Ricardo Linares-Saldana, Andrew Dobria, Stephanie M. Cologna, Camerron M. Crowder, Leslie N. Aldrich, Swetha Gowrishankar
A small molecule modulates neuronal lysosome positioning and function, reducing amyloid-beta levels and rescuing pathologies in human neurons and zebrafish.
bioRxiv · Nov 4, 2024 · PreprintCell Biology