Circadian and permanent pools of extracellular matrix co-exist in tendon tissue, but have distinct rates of turnover and differential responses to ageing
Anna Hoyle, Joan Chang, Marie F.A. Cutiongco, ronan.ocualain not provided, Stacey Warwood, David Knight, Qing‐Jun Meng, Karl E. Kadler, Joe Swift
The paper uses stable isotope labeling and mass spectrometry to show that tendon ECM has circadian and permanent pools with distinct turnover rates, which change with age.
bioRxiv · Aug 9, 2024 · PreprintMolecular Biology