The SH Protein of Mumps Virus is a Druggable Pentameric Viroporin
Kira Devantier, Trine Lisberg Toft‐Bertelsen, Andreas Prestel, Viktoria M. S. Kjær, Cagla Sahin, Marco Giulini, Stavroula Louka, Katja Spieß, Asmita Manandhar, Katrine M. Qvortrup, Trond Ulven, Bo Hjorth Bentzen, Alexandre M. J. J. Bonvin, Nanna MacAulay, Birthe Brandt Kragelund, METTE MARIE ROSENKILDE
This study identifies the mumps virus SH protein as a pentameric viroporin and shows it functions as a chloride channel inhibited by BIT225.
Science Advances · Jun 6, 2025Peer-reviewedBiophysics