Trine Lisberg Toft‐Bertelsen

This study identifies SPAK as a key regulator of CSF secretion via TRPV4 activation and NKCC1, suggesting it as a pharmacological target for hydrocephalus.

This paper develops a method to discover PANX1 modulators using DNA-encoded library screening with stabilized membrane protein nanoparticles and validates hits through biophysical and electrophysiological assays.

This study identifies the mumps virus SH protein as a pentameric viroporin and shows it functions as a chloride channel inhibited by BIT225.

This study identifies membrane transporters involved in cerebrospinal fluid (CSF) secretion and shows their role in modulating intracranial pressure.

The paper profiles the transcriptome of rat choroid plexus to identify transport mechanisms and regulatory pathways involved in cerebrospinal fluid secretion.

This study identifies lysophosphatidic acid (LPA) as a biomarker for posthemorrhagic hydrocephalus and shows it drives CSF accumulation through TRPV4-induced hyperactivation of NKCC1.

This study shows acetazolamide reduces intracranial pressure directly by acting on the choroid plexus in rats, without relying on systemic effects.