Pharmacological arginine deprivation renders pancreatic cancer cells susceptible to senolysis and inhibition of the integrated stress response
Laura Mainz, Mohamed A.F.E. Sarhan, Lisa Schlicker, Stefanie Kirner, Jennifer P. Morton, Elena Hartmann, Andreas Rosenwald, Ursula Eilers, Christina Schuelein‐Voelk, Werner Schmitz, Apoorva Baluapuri, Martin Eilers, Elmar Wolf, Markus E. Diefenbacher, Almut Schulze, Mathias Tillmann Rosenfeldt
This study shows that arginine depletion induces senescence and stress response in pancreatic cancer cells, making them susceptible to senolysis and stress response inhibition.
bioRxiv · Aug 4, 2026 · PreprintCancer Biology