Markus E. Diefenbacher

This study identifies LXR as an oxysterol-sensing suppressor of ferroptosis by promoting lipid remodeling that reduces lipid peroxidation.

This study shows that arginine depletion induces senescence and stress response in pancreatic cancer cells, making them susceptible to senolysis and stress response inhibition.

This paper develops R4VPs, PROTAC-like compounds that induce ferroptosis in aggressive cancers while sparing normal cells, showing efficacy against therapy-resistant melanoma and sarcomas.