Lisa Schlicker

Catabolism of extracellular glutathione is a driver of metastasis formation

The paper identifies extracellular glutathione catabolism as a driver of metastasis by enabling proliferation and oxidative stress resistance in metabolically challenging microenvironments.

A novel role for Oxaloacetate Decarboxylase FAHD1 in cardiomyocyte maturation

This study identifies FAHD1 as a critical regulator of mitochondrial function and cardiomyocyte maturation, showing its deficiency impairs respiration, disrupts sarcomere organization, and leads to cardiac dysfunction.

Pharmacological arginine deprivation renders pancreatic cancer cells susceptible to senolysis and inhibition of the integrated stress response

This study shows that arginine depletion induces senescence and stress response in pancreatic cancer cells, making them susceptible to senolysis and stress response inhibition.

GLYATL1 is associated with metabolic and epigenetic changes and with endocrine resistance in luminal breast cancer

This study identifies GLYATL1 as a mediator of endocrine resistance in luminal breast cancer by promoting metabolic and epigenetic changes that counteract estrogen deprivation.

CAMK2-NR4A1 signaling initiates metabolic substrate switching to induce heart failure with reduced ejection fraction

The paper identifies CAMK2-NR4A1 signaling as a driver of metabolic substrate switching in heart failure with reduced ejection fraction, linking it to cardiac dysfunction through glucose utilization and lipid depletion.