Apoorva Baluapuri

Nascent transcription profiling identifies H3K36 methylation as a custodian of the somatic transcriptome

The paper identifies H3K36 methylation as critical for maintaining transcriptome fidelity in metazoans by suppressing aberrant initiation in heterochromatin.

Pharmacological arginine deprivation renders pancreatic cancer cells susceptible to senolysis and inhibition of the integrated stress response

This study shows that arginine depletion induces senescence and stress response in pancreatic cancer cells, making them susceptible to senolysis and stress response inhibition.

Dual Modes of Gene Regulation by CDK12

This study shows CDK12 inhibition both downregulates and upregulates gene expression, with implications for cancer therapy.

GPCR Antagonism via Antibody-Mediated Rewiring of Receptor Trafficking and Degradation

This paper introduces GTACs, bispecific antibodies that selectively downregulate GPCRs via endocytosis and lysosomal degradation, showing high potency and selectivity for therapeutic targets.

Nucleolar detention of NONO shields DNA double-strand breaks from aberrant transcripts

The paper shows that NONO relocalizes to the nucleolus via diNARs to shield DNA breaks from aberrant transcripts, promoting repair.