The primary cilium controls programmed cell death via its proteasome-regulating function
Antonia Wiegering, Sandra Hägele, Stefanie Kuschel, Monika Böddeker, Christiane Ott, Sophie Saunier, Tilman Grune, Ulrich Rüther, Sylvie Schneider‐Maunoury, Peter Walentek, Thorsten Pfirrmann, Christoph Gerhardt
The paper shows that primary cilia regulate programmed cell death by controlling the proteasomal degradation of MOAP1 through ciliopathy proteins like RPGRIP1L, TCTN1, and CEP290.
bioRxiv · Jan 8, 2026 · PreprintCell Biology