Christoph Gerhardt

CiliAI: Automated segmentation and compartment specific fluorescence quantification of primary cilia in confocal microscopy images

CiliAI automates cilia segmentation and fluorescence quantification in confocal images, showing agreement with manual methods and reducing analysis time.

Oxidative stress causes a reversible decrease of deubiquitylases activity in old vertebrate brains

This study shows oxidative stress reduces DUB activity in aging brains, which can be reversed with antioxidants, suggesting a reversible cause of proteostasis decline.

The primary cilium controls programmed cell death via its proteasome-regulating function

The paper shows that primary cilia regulate programmed cell death by controlling the proteasomal degradation of MOAP1 through ciliopathy proteins like RPGRIP1L, TCTN1, and CEP290.

Gain-of-function mutation in Gli3 causes ventricular septal defects

The paper shows that a gain-of-function mutation in Gli3 causes ventricular septal defects by impairing PDGFR signaling, suggesting potential therapeutic targets.