Caspase-2 kills cells with extra centrosomes
Dario Rizzotto, Vincenza Vigorito, Patricia Rieder, Filip Gallob, Gian Mario Moretta, Claudia Soratroi, Joel S. Riley, Florian Bellutti, Stefano Li Veli, Alessia Mattivi, Michael Lohmüller, Sebastian Herzog, Beat C. Bornhauser, Etienne D. Jacotot, Andreas Villunger, Luca L. Fava
The paper shows that caspase-2 triggers apoptosis in cells with extra centrosomes, preventing polyploidization through mitochondrial pathways.
Science Advances · Oct 30, 2024Peer-reviewedCell Biology