Filip Gallob

The paper identifies V-ATPase inhibition as a trigger for apoptosis via GCN1/GCN2 kinase signaling and MCL-1 depletion, revealing a therapeutic target in certain cancers.

This study shows that tRNA thiolation defects in humans cause proteostasis and tissue homeostasis issues, but mice with similar defects develop normally.

The paper shows that caspase-2 triggers apoptosis in cells with extra centrosomes, preventing polyploidization through mitochondrial pathways.