Andreas Villunger

This paper develops an ex vivo model using organ-derived ECM scaffolds to study cancer cell invasion, showing organ-specific invasion patterns that match clinical observations.

This study identifies dual roles of ERH in primary miRNA biogenesis, showing it suppresses miRNA processing through DGCR8 binding and facilitates cluster assistance independently of this interaction.

The paper identifies V-ATPase inhibition as a trigger for apoptosis via GCN1/GCN2 kinase signaling and MCL-1 depletion, revealing a therapeutic target in certain cancers.

This study shows that TET2 loss increases lymphoma penetrance and promotes survival of premalignant B cells in MYC-driven lymphoma by reducing apoptosis.

This study shows the PIDDosome restricts cardiomyocyte polyploidization during postnatal heart development through p21/Cdkn1a, independent of p53.

This study shows that tRNA thiolation defects in humans cause proteostasis and tissue homeostasis issues, but mice with similar defects develop normally.

This study maps the metabolic complex genetic interaction network of chromosome 4p loss in basal breast cancer to identify targetable vulnerabilities.

This study shows WEE1 inhibitors work better with mRNA translation defects by activating GCN2, and suggests ways to reduce off-target effects.

This study shows that sequential auto-processing of PIDD1 is essential for controlling ploidy in liver and heart development, with distinct roles for caspase-2 in different cell types.

The paper shows that caspase-2 triggers apoptosis in cells with extra centrosomes, preventing polyploidization through mitochondrial pathways.

The paper shows that precise centriole counts are essential for B cell development but not for immune function.

The paper identifies SAFB2 as a co-factor enabling the processing of suboptimal miRNA stem-loop structures in clustered primary transcripts.

This study shows that CHK1 is essential for hematopoietic stem cell survival and fetal hematopoiesis, and that its inhibition causes severe DNA damage and prevents HSC expansion.