Developmental HCN channelopathy results in decreased neural progenitor proliferation and microcephaly in mice
Anna Katharina Schlusche, Sabine Ulrike Vay, Niklas Kleinenkuhnen, Steffi Sandke, Rafael Campos-Martín, Marta Florio, Wieland Β. Huttner, Achim Tresch, Jochen Roeper, Maria Adele Rueger, Igor Jakovčevski, Malte C. Stockebrand, Dirk Isbrandt
This study shows that HCN-channel dysfunction in neural progenitors causes microcephaly by disrupting cell cycle progression and proliferation in mice.
Proceedings of the National Academy of Sciences · Aug 24, 2021Peer-reviewedNeuroscience